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Detection of Exocrine Pancreatic Insufficiency in Patients With Diarrhea and Bloating

December 30, 2019


In this trial, investigators are looking at how exocrine pancreatic insufficiency (EPI) is present in patients with bloating or diarrhea. They will see if early detection and management of EPI will help relieve symptoms and see if it is the main cause of those symptoms. Investigators will include fecal elastase-1 in the tests for patients presenting with diarrhea and/or bloating.


Study Information

In this study, investigators will recruit 200 participants from the St. Luke Baylor’s Clinic during their clinic visit.


Inclusion Criteria


  • Patients aged 18 to 80 years old who presents to the gastroenterology clinic with main complaints of diarrhea
  • Patients aged 18-80 years old who presents to the gastroenterology clinic with main complaints of flatulence, and/or bloating
  • Patients with known IBS, microscopic colitis or celiac disease diagnosis will be included.
  • Patients on Diphenoxylate, loperamide or cholestyramine will be included.


Exclusion Criteria


  • Known chronic pancreatitis, recurrent acute pancreatitis or autoimmune pancreatitis.
  • Known Pancreatic cancer
  • Prior History of distal pancreatectomy or Whipple surgery.
  • Prior history of gastric bypass surgery or any Roux en Y gastrojejunal anastomosis.
  • Pregnant Patients



Baylor College of Medicine

Houston, Texas, United States, 77030

Contact: Mohamed Othman, MD    713-798-0950  



Baylor College of Medicine

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