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Film Array Gastrointestinal Panel Compared to Usual Care for ED Evaluation of Infectious Diarrhea

December 30, 2019

Overview

In this study, investigators will use the lab test Film-Array Gastrointestinal (GI) Panel, which can identify the bacteria or viruses that may cause diarrhea. The doctor will then be able to understand the cause of the diarrhea to administer proper treatment and optimal use of antibiotics. 

 

Study Information

In this study, 176 participants will be split into experimental and control groups. The experimental group will receive the GI panel test and receive care from a physician according to the results. In the control group, the physician will not be informed of the results of the test but will receive care.

 

Inclusion Criteria

 

  • Presumed infectious diarrhea (3 or more loose stools in past 24 hours)
  • Must have one of the 3 following features or symptoms lasting more than 7 days:
  1. Symptoms greater than 24 hours;
  2. Dehydration (defined as the need for intravenous fluid or per clinician’s judgement ((based on the general appearance and alertness of the patient, the pulse, the blood pressure, the presence or absence of postural hypotension, the mucous membranes and tears, sunken eyes, skin turgor, capillary refill, and jugular venous pressure.))
  3. Inflammation (defined as fever (greater than 100.1), blood in stool per patient, DRE, or tenesmus.)

 

Exclusion Criteria

 

  • Chronic Symptoms (>14 days)
  • Inability to Follow- Up (i.e. no telephone)
  • Prisoner
  • Likely non-infectious cause of diarrhea (Crohn’s disease, radiation colitis, irritable bowel syndrome, or celiac disease)
  • Confirmed C. Diff Diarrhea
  • Unable to provide written consent
  • Non- English speaker

 

Location

The George Washington University, Department of Emergency Medicine

Washington, District of Columbia, United States, 20037

Contact: Andrew C Meltzer, MD, MS    202-741-2952 ameltzer@mfa.gwu.edu  

Contact: Maxine LeSaux    202-741-2917 mlesaux@mfa.gwu.edu  

Principal Investigator: Andrew C Meltzer, MD, MS 

 

Sponsors/Collaborators

Andrew Meltzer

BioFire Diagnostics, LLC

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